GPR158 in pyramidal neurons modulates social novelty思维导图
锥体神经元中的GPR158调节社会新颖性介绍
树图思维导图提供 GPR158 in pyramidal neurons modulates social novelty 在线思维导图免费制作，点击“编辑”按钮，可对 GPR158 in pyramidal neurons modulates social novelty 进行在线思维导图编辑，本思维导图属于思维导图模板主题，文件编号是：e2b2d381f060d0b918bda0b7af285c2f
思维导图大纲
GPR158 in pyramidal neurons modulates social novelty思维导图模板大纲
Social novelty deficit in KO mice. Behavioral tests with KO mice, to evaluate sociability, social novelty, stereotyped behaviors and cognitive ability
Deciding mPFC as the target area via c-Fos. mPFC, CA1, CA3, DG and VMH were investigated. mPFC: Higher expression, and larger difference
E-I imbalance: ELISA-Glutamate reduction
Presynaptic
TEM: Reduction of glutamate vesicles
子主题 1
Golgi: dendritic spines
Postsynaptic
Reduced amplitude and decay time of EPSC
Reduced expression of GluN2B and p-GluB2B
Mechanism verification
Recapitualate tests
CamK2aCre;Gpr158flox/flox mice
shRNA-Gpr158 into mPFC
Rescue tests
Gpr158 re-expression in mPFC with Lenti-virus
Chemogenetic enhancement of CamK2A+ neurons in mPFC
相关思维导图模板
树图思维导图提供 52 The Impact of Internet Usage on Social Interaction 在线思维导图免费制作，点击“编辑”按钮，可对 52 The Impact of Internet Usage on Social Interaction 进行在线思维导图编辑，本思维导图属于思维导图模板主题，文件编号是：f0589814954fec86174a1f2864eb9289
树图思维导图提供 A Secure System For Pervasive Social Network-Based Healthcare 在线思维导图免费制作，点击“编辑”按钮，可对 A Secure System For Pervasive Social Network-Based Healthcare 进行在线思维导图编辑，本思维导图属于思维导图模板主题，文件编号是：3fe009af1ca6673fe665df5e689aa6ad
沪公网安备 31011502019485号
上海工商